35 years man with a dilated heart

 
35 year old man working as a food caterer  presented to our OPD with the chief complains of 
Dyspnea at rest since 5 days
Cough with expectoration since 5 days
Bilateral pedal edema since 4 days
Abdominal distension since 3 days

Patient was born and brought up in *********. He was born to a farmer and a housewife. He has 2 elder siblings, his elder sister is married to an advocate and has 2 children and his elder brother is working as a software engineer. He pursued his degree in electronics but was not successful in finding a job in this branch, so he moved to another state 10 years back and started working in a food catering business along with his friends. During his stay outside his hometown, he says he used to often feel lonely and used to often consume whiskey along with his friends which got to a point that he started consuming around 180 ml of whiskey everyday. He also tells that he would occasionally smoke cigarette once in a while along with his friends. In those 10 years he never paid a visit to his hometown due to financial issues and decided not to get married anytime soon as he wanted to settle the financial issues his family was facing. 
He was apparently alright until one morning in November 2019 when he had high fever with chills and visited a local hospital where he got admitted and was diagnosed with malaria for which he received treatment.
In Dec 2019 he says he started feeling breathless while climbing up the stairs which progressed over the next 5 days to such an extent that he even felt dyspneic even at rest and had dry cough on and off. He says that his dyspnea and cough aggravated on laying in bed. He gradually developed bilateral pedal edema followed by abdominal distension over the next few days which alarmed him and he decided to pay a visit to a doctor. He visited a local hospital and was put on some medications ( no documentation ) which patient couldn't recall of. Since it did not improve his symptoms he visited our hospital in January 2020.






 His blood picture, renal and liver parameters were in within the normal range. 
On routine investigations his HbA1c was found to be 8.4 %.
His Ultrasonography of abdomen revealed Grade 1 fatty liver ( probably secondary to his alcohol intake), mild ascites, Right moderate pleural effusion.
2DEcho was done which revealed that all the 4 chambers to be dilated with an ejection fraction of 27, global hypokinesia, severe MR, trivial AR, severe LV dysfunction with mild PAH, dilated IVC (2.3cm)
A diagnosis of HEART FAILURE WITH REDUCED EJECTION FRACTION 
DENOVO TYPE 2 DM
and he was started on 
Tab Lasix 80mg in the morning, 40mg in the afternoon and evening
Tab Isosorbide mononitrate 10mg twice a day
Tab Hydralazine 25mg 
Tab Telma 40mg
Tab Metformin 500mg once a day
and was advised for fluid and salt restriction
He was advised for a coronary angiogram for which he visited Hyderabad. CAG was performed on 24th of January 2020 which turned out to be normal and he was started on Tab Vymada 50mg and Tab Met XL 12.5mg
( Sacubitril 26 mg and Valsartan 24 mg) along with Tab Ecosprin AV (75/20)


On regular at home monitoring of blood glucose levels which were within the normal range, he stopped taking Tab Metformin. 

On 14th March 2020 he paid a visit to our hospital with the similar complains and a review scan of 2DEcho was done which revealed end point septal separation distance to be increased and Tab Vymada was increased to 100mg. 


On July 28th, 2020 he presented to our OPD with the complains of Dyspnea at rest since 5 days which apparently aggravates when the patient is in supine posture and he also complains of  occasional cough with scanty mucoid, non blood tinged sputum especially while he is asleep. He says he developed bilateral pedal edema extending upto his knee over the past 4 days followed by abdominal distension. 

Patient appeares to have gained weight with abdominal girth measuring 116cm. 
 and he weighed 101 kg



Icterus was present





He weighs 93 kgs now

He appeared to be in respiratory distress with a respiratory rate of 28 cycles per minute and his saturation was  at 98 % on room air.
His heart was beating at 120 bpm with a blood pressure of 100/70mmhg.
He was afebrile.
His JVP was raised
His apex beat was in 6th intercostal space, 1cm lateral to midclavicular line.
On auscultation, S1  S2 +
His lungs were clear on auscultation
His abdomen was soft to palpate and bowel sounds were heard. 










His 2Decho showed dilated chambers with global hypokinesia, ejection fraction of 26 %, severe MR, mild TR, Trivial AR, mild pericardial effusion, mild PAH and IVC measuring 1.7 cms.

Hemogram:
Hb - 13 g/dl
TLC - 7000 cells/cumm
Platelet count - 2.28 L/cumm

Complete Urine Examination:
showed no albumin, sugars, RBCs
2-4 Pus & epithelial cells

Renal Function Test :
Urea - 53 mg/dl
Creatinine - 1.4 mg/dl
Uric Acid - 9 mg/dl
Calcium - 9.6 mg/dl
Phosphorus - 3.3 mg/dl
Sodium -  133 mEq/L
Potassium - 4 mEq/L
Chloride - 98 mEq/L

Liver Function Test: 
Total Bilirubin - 4.60 mg/dl
Direct Bilirubin - 2.42 mg/dl
AST - 56 IU/L
ALT - 44 IU/L
ALP - 129 IU/L
Total Proteins - 6.2 gm/dl
Albumin - 3.9 gm/dl

The Patient is currently on fluid and salt restriction
Along with INJ LASIX 40MG TID
TAB VYMADA 100 MG BD
TAB VALSARTAN 80MG OD
TAB MET XL 12.5MG OD
TAB DYTOR PLUS 10/25 OD




Patient has come back after 1 month 
with the complains of 
Dyspnea since 2 days 
Orthopnea since 2 days
Loss of appetite since 2 days
Dyspnea exaggerated on walking 
Says he has been getting up from sleep because of shortness of breath which is being releaved on sitting posture
He also tells us he doesn't feel like eating since 2 days 
No complains of cough, hemoptysis, chest pain or palpitations 
Reduced pedal edema
Pallor +
Icterus +
RR - 20 cpm
PR - 78 bpm
Bp - 140/80
Cvs - S1,S2 +
Lungs - clear





We had a look at his 2DEcho












His RBS was 111 mg/dl



History updated today by Dr Aashita PGY2 below:


35 year old man working as a food caterer from
presented to our OPD with the complains of :
Dyspnea since 5 days
Cough since 5 days
Bilateral pedal edema since 4 days
Followed by
abdominal distension since 3 days
Patient was born and brought up in xxxx . He was born to a farmer and a housewife and has 2 siblings, an elder sister who is a houswife and has been married to an advocate and an elder brother who is a software engineer. He has completed his degree in electronics and has been working as a food caterer in xxxx the last 10 years. In these last 10 years he has been regularly consuming alcohol around 180 ml of whiskey everyday along with his other friends. He says he used to sometimes feel lonely and he decided not to get married unless the financial situation of his family settles.

He was apparently completely alright until December 2019 when he developed dyspnea which was sudden in onset and was associated with occasional cough on and off and was also associated with bilateral pedal edema and abdominal distension. He says his dyspnea used to aggravate on exertion and it wasnt associated with chest pain, palpitations, hemoptysis or reduced urine output. Though he tells it used to aggravate on laying position.

He was taken to a hospital in xxxx where they put on some unknown medications for 10 days. He visited our hospital as his symptoms didn't relieve with those medications.
He was admitted in our hospital for few days and was diagnosed with dcmp with an ejection fraction of 36 %. His HbA1c was found to be 8.4 and was diagnosed as type 2 DM and the patient was started on OHAs and was stopped on OHAs after 3 days. He was advised to get an angiogram done.
He visited NIMs hospital where CAG was done and was reported as normal. He was started on Ecosprin, Tab Vymada ( valsartan and sacubitril), Dytor plus 10/20. He stopped taking ecosprin after 2 months and was advised to even take oral form of Lasix 40mg twice a day on regular visits to our hospital.
He now presented to us, dyspneic with a respiratory rate of 27 cpm and tells us he has been dyspneic the last 5 days which aggravated especially on climbing stairs and on laying on the bed associated with occasional cough with scanty mucoid non blood tinged sputum. In the past 4 days he has even developed bilateral pedal edema followed by abdominal distension.

More discussion around this patient here:https://m.facebook.com/story.php?story_fbid=10160143900319502&id=800154501

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